Guisti (Arabic: جويستي) is a town located in southeastern of Ali Sabieh Region.

It is situated about 32 kilometres (20 miles) Southeast of Ali Sabieh, near the borders with Somaliland and Ethiopia.

Guisti is in the Region of Ali Sabieh, its situated on a spur of a plateau, an upland characterized by one major wadi which run beside it.

Guisti is near the borders of Somaliland to the east and Ethiopia to the south.

The town inhabitants belong to various mainly Afro-Asiatic-speaking ethnic groups, with the Issa Somali predominant.