Architect P. Thornton Marye designed the Mission Revival style terminal for the Mobile and Ohio Railroad.

Louisville & Nashville passenger service in Mobile called at a separate L&N station located about 1 mile distant.

[1] It had suffered neglect, extensive interior alteration, and partial removal of the train shed by this time.

The Gulf, Mobile and Ohio Railroad vacated the old terminal building in 1986 and for fifteen years it suffered from demolition-by-neglect.

[2] In 2001 the City of Mobile and a private company invested more than $18 million to restore the local landmark with the developer taking advantage of the Federal Historic Preservation Tax Incentive program.