He is the chairman and co-founder of Fosun International Limited, and a representative of the 12th Chinese People's Political Consultative Conference.

[3] In 1992, Guo founded Guangxin Technology Development Company Ltd, with friends Liang Zinjun and Tan Jian,[4] which was among the first to use scientific methods in market research in mainland China.

[14] In July 2016 Guo’s Fosun International purchased the Wolverhampton Wanderers Football Club a professional association football club based in Wolverhampton, West Midlands, England for a reported £45 million from previous owner Steve Morgan, Wolves went on to clinch the 2017–18 Championship title, to return to the Premier League after a 6-year absence.

[25] Through the auspices of the Fosun Foundation, Guo has donated an aggregate of up to 600 million RMB to charity causes to help fight poverty, improve access to education and provide natural disaster relief.

[26] On 11 December 2015, it was reported that Guo has been detained by police, was "assisting authorities with an investigation", and had been "linked to a corruption court case in August".