Gustavo A. Madero is the northernmost borough (demarcación territorial) of Mexico City.

The Treaty of Guadalupe Hidalgo, which ended the Mexican–American War of 1846–1848, was signed in Gustavo A. Madero.

The area houses the Basílica de Guadalupe, the shrine of Our Lady of Guadalupe at the foot of Tepeyac Hill, where Roman Catholics believe the Virgin Mary appeared to the indigenous Mexican Juan Diego Cuauhtlatoatzin in 1531.

Being the northernmost borough, the Northern Central Bus Station (Terminal Central del Norte) is located here, providing constant bus service to all major cities in the northern and western part of the country.

On Sundays, the San Felipe de Jesús Tianguis in the neighborhood of the same name, is Latin America's largest tianguis or street market, with 30,000 vendors and stretching seven kilometers.