The station and its surrounding area are named this way because there used to be a hippodrome and Potrero's pictogram features the silhouette of a horse head behind a fence to reference a paddock.

Since its opening, the station has experienced some incidents, including a train crash in the southbound tunnel, where one person died and 106 others were injured, and a sinking caused by local subsidence.

Potrero is an at-grade metro station situated along Avenida de los Insurgentes, in Gustavo A. Madero, Mexico City.

[14] On 14 December 2018, a private vehicle crashed into the walls at the Insurgentes Norte and Victoria entrance after being struck by a public bus with no injuries reported.

[16] Two trains collided inside the Potrero–La Raza interstation tunnel while both headed toward Indios Verdes metro station on 7 January 2023.

Subsequently, the Mexico City government deployed members of the National Guard to monitor metro stations, claiming—without providing evidence—that opponents sabotaged the system.

[21] The metro union added that there is "a deformation in the slab and the track elements, including rails, guide bars, and insulators, and sinkholes [...] which create problems in train operations and the execution of corrective maintenance work.

In addition, they identified deformations in the track section between Potrero and Deportivo 18 de Marzo, which causes swaying during train operations.