U.S. Route 6 passes through the center of town, leading east (upriver) 7 miles (11 km) to Eagle, the county seat.

[3] This climate type is dominated by the winter season, a long, bitterly cold period with short, clear days, relatively little precipitation mostly in the form of snow, and low humidity.

Gypsum is the location of the Eagle County Regional Airport (EGE), a popular regional airport used in the winter to transport skiers to nearby Vail, 35 miles (56 km) to the east.

Gypsum is also the location of several CORE TRANSIT stops, there are stops at Jules Dr, Eagle Valley High School, Eagle County Regional Airport, Cooley Mesa Rd, and Navajo Rd.

The facility produces a variety of wallboard products, which is shipped by both rail and truck.

The company also operates an open pit gypsum mine in the hills north of town.

Unlike most surface mines, which utilize drill and blast methods to recover material, the Eagle mine uses machines similar to pavement mills (Wirtgen 2200 SM Surface Miners) to cut 6-inch-deep (150 mm) swaths through the relatively soft rock.