The hôtel was likely built by a wealthy bourgeois, Jean Canelle (1503–1562), later Lord of Vaulichères, Receiver of Aids and Taxes in Tonnerre, after 1556.

The Countess of Tonnerre, a friend of the Canelles, stayed here on many occasions.

Charles de Beaumont, Chevalier d'Éon, was born at the hôtel on 5 October 1728.

Heavily restored in 1888, the controversial work featured decorations and frescos by the painter Georges Henri Carré, completed in 1907.

The decoration of the building makes it an example of Renaissance constructions in Paris: corner turret, skylights, mullioned windows, niches, shells, friezes decorated with extreme delicacy, arabesques, fauns, etc.