As of 2024, it was the fourth-largest manufacturer of adhesives and sealants in the world, employed approximately 7,500 people, and had revenues of US$3.57 billion.

It was run by the Fuller family until 1941, when Elmer L. Andersen purchased a majority stake in the company and assumed leadership.

Fuller expanded its position in the consumer goods market in 1956 with the construction of a plant in Minneapolis to make packing tape.

Fuller acquired the Costa Rican company Kativo Chemical Industries in 1967, expanding its portfolio to include paints and inks.

Fuller and 22 other companies joined together to form the Minnesota Keystone Program, a group of corporations that agreed to donate a portion of their pre-tax profits to charity.

[13] The company became a member of the Fortune 500 in 1983 and was recognized by Robert Levering and Milton Moskowitz as one of the "100 Best Places to Work in America".

Fuller sold its powder coating division to Valspar and purchased Roanoke Companies Group for US$270 million.

[17] In the 1990s, reports were published about the popular use of adhesives as an inhalant among poor children in Central America, though the company had been aware of the issue for years prior.

Fuller adhesives were common among those abused and the company reportedly declined to add a noxious oil to the glue to discourage its use as an inhalant, citing exposure concerns for legitimate users of the product and saying that adding the toxin would not address the deeper social issues that led to abuse.

It continued to sell the product for commercial and industrial applications, which drew criticism from advocacy groups who favored a total cessation of the sale of Resistol.

The company changed the formula of Resistol in 1994, swapping the compound toluene for a less dangerous and addictive substance, cyclohexane.

[20] In 1995, the company was sued for the wrongful death of Joel Linares, a 16-year-old Guatemalan boy who allegedly died from side effects of inhaling Resistol.

Fuller manufactures adhesives for a variety of applications, including those used in construction, engineering, electronics, hygiene products, and food packaging.

Fuller employs approximately 7,500 people, is headquartered in St. Paul, Minnesota, and is led by chief executive officer Celeste Mastin.

Fuller was recognized as a "socially responsible" investment for the company's efforts to properly dispose of industrial waste, conserve energy, and for donating property near its headquarters to create a nature reserve.