[1] The genomic DNA of eukaryotic cells is wrapped around special protein molecules known as histones.
[6] The current understanding and interpretation of histones come from two large scale projects: ENCODE and the Epigenomic roadmap.
This led to chromatin states which define genomic regions by grouping the interactions of different proteins and/or histone modifications together.
Chromatin states were investigated in Drosophila cells by looking at the binding location of proteins in the genome.
[8] Different developmental stages were profiled in Drosophila as well, an emphasis was placed on histone modification relevance.
[9] A look into the data obtained led to the definition of chromatin states based on histone modifications.