[2] The serotype identifies the more common HLA-B*57 gene products.
HLA-B*5701 is associated with drug-induced inflammatory disease of the skin.
[3] Abacavir is an antiretroviral drug used in treatment of HIV, however in sensitive individuals fever, skin rash, fatigue, gastrointestinal symptoms such as nausea, vomiting, diarrhea or abdominal pain and respiratory symptoms such as pharyngitis, dyspnea, or cough can develop.
FDA has advised that people from at-risk ethnic groups, (see alle distribution table) be screened prior to drug-therapy.
[4] [Note: phenotype frequencies are roughly double allele frequencies -tabled values- when allele frequency is less than 30%] The mechanism by which abacavir causes this type 4 hypersensitivity reaction is by binding in the antigen-binding cleft of the HLA-B*57:01 protein, allowing new, "non-self" antigens to bind and be presented to T cells.