HLA-DR16(DR16) is a HLA-DR serotype that recognizes the DRB1*1601, *1602 and *1604 gene products.
DR16 is found in the Mediterranean at modest frequencies.
DR16 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR15 antigens.
DR16 is associated with Chaga's cardiomyopathy,[2] rheumatic heart disease,[3] coronary artery ectasia,[4] and chronic discoid lupus erythematosus.
[5] DRB1*1601 is associated with tuberculosis risk[6] DRB1*1602: Juvenile rheumatoid arthritis,[7] rheumatic heart disease,[3] Takayasu arteritis Archived 2007-08-07 at the Wayback Machine,[8] systemic sclerosis (SSc) & anti-DNA topoisomerase I (anti-topo I) antibody,[9][10] melioidosis (Burkholderia pseudomallei infection)[11] DRB1*1601:DQA1*0102:DQB1*0502 haplotype is associated with tubeculousis risk [6] HLA-DR16 is genetically linked to HLA-DR51 and HLA-DQ5 serotypes.