In 1759, under the command of Captain James Webb, Antelope was attached to Commodore William Boys' squadron, which had been blockading François Thurot in Dunkirk throughout the summer and early autumn.

On 15 October, when the squadron had been driven off station during a gale, Thurot made his escape with six frigates and corvettes carrying 1300 troops and sailed to Gothenburg.

In 1762, Antelope was stationed in Placentia Bay, Newfoundland, under the command of Commodore Thomas Graves, who was the Colony's Naval Governor.

A French fleet from Brest, under M. de Ternay, with 1500 troops commanded by the Comte d'Haussonville, sailed into St. John's and captured the town on 24 June.

Captain Graves immediately sent word to Commodore Lord Colville at Halifax who joined him in blockading the French, and brought troops over from Louisbourg on Cape Breton Island on 11 September.

On her way home to England Antelope under Admiral Clark Gayton she encountered HMS Marlborough, under Captain Thomas Burnett, which had sailed from Havana as part of the escort of a convoy of prizes and transports, but had become separated in very heavy weather.