HMS Newcastle was a 50-gun fourth rate ship of the line of the Royal Navy, built by Peirson Lock at Portsmouth Dockyard and launched in 1750 for active service during the Seven Years' War against France.

Principally engaged in defending British settlements in India, she was wrecked in a storm off Pondicherry in January 1761.

Newcastle was able to leave harbour, but the wind shifted, impeding her and eventually driving her ashore two miles south of Pondicherry.

When they anchored the sea overwhelmed them and they both foundered, each with the loss of almost all on board.

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