HMS Preston was a 50-gun fourth rate ship of the line of the Royal Navy, built at Deptford Dockyard by Adam Hayes to the draught specified in the 1745 Establishment, and launched on 7 February 1757.

[2] From January 1774 until April 1776 she was under command of Captain John Robinson with a crew of 350 men.

On 13 August 1778, cut off from her squadron by a storm, she encountered the French 74-gun Marseillois, which she fought indecisively.

Taking part in the Battle of Dogger Bank (1781) where she was disabled, with her commander, Captain Alexander Graeme losing an arm, she was sailed back to the Thames by Lieutenant Saumarez[5]: 51 From March 1783 until April 1784 she was under command of Captain George Martin.

[6] In 1785, Preston was converted to serve as a sheer hulk, and she was eventually broken up at Woolwich in January 1815.