The hospital's staff of 1,400 physicians and dentists covers the full range of medical and dental specialties and sub-specialties.

It is also a member of the Association of American Medical Colleges' New Jersey Council of Teaching Hospitals (NJCTH).

In September, 2021 hospital administration announced that they were upgraded to level 1 trauma center status by the American College of Surgeons.

[12][13] Also that year, U.S. News & World Report's Best Hospital Ranking listed HUMC #1 in New Jersey and #7 in New York Metro.

[14] HUMC's campus houses the Hackensack University Medical Plaza building, which was constructed in 1998, and opened on September 21, 1998, and is one of the largest adult ambulatory care facilities in the United States.

The John Theurer Cancer Center (JTCC) at HUMC performs research and oncology services.

[24] Areas of concentration include blood and marrow stem cell transplantation, lymphoma, leukemia, multiple myeloma, neuro-oncology, cutaneous malignancy, gastrointestinal, geriatric, head and neck, thoracic, urologic, breast, and gynecologic.

[27] As of 2007, Hackensack University Medical Center provides advanced life support coverage to 35 municipalities and operates five paramedic fly-cars.