Hannah Minthorne Tompkins (August 28, 1781 – February 18, 1829) was the wife of Daniel D. Tompkins, the governor of New York and later vice president of the United States, and thus was the first lady of New York 1807 to 1817 and then the second lady of the United States from 1817 to 1825.

[2][3] At the time of the marriage, her father was Assistant in the Common Council, and young Tompkins had designs on a political career.

Hannah was ill the year before her husband became vice president, and she did not attend his inauguration.

[4] From 1800 to 1814, the couple had eight children, including Arietta Minthorn Tompkins (born July 31, 1800), who married a son of Smith Thompson in 1818, and (Mangle) Minthorne Tompkins (December 26, 1807 – June 5, 1881), who was the Free Soil Party candidate for governor of New York in 1852.

She and her husband are buried in the Minthorne family vault at St. Mark's-in-the-Bouwerie in lower Manhattan.