Continuing on I-83, the beltway parallels Paxton Street (formerly US 322), passing the former Harrisburg Mall as the road approaches the Eisenhower Interchange.

Exit 67A is for US 22 east, Cameron Street, which is where the Pennsylvania Farm Show Complex & Expo Center is located (a half mile south of the beltway).

The beltway makes a southerly turn just beyond the bridge, near the western end of the Susquehanna Water Gap of Blue Mountain.

The segment between US 22 in Colonial Park and US 422 on the site of the future Eisenhower Interchange opened in 1954, designated initially as part of Bypass US 230 (PA 230 after 1961).

[6] Also opened was a 4.5 mile freeway west from I-83 in Lemoyne to connect with US 15 in Camp Hill and US 11 in Hampden Township, where those highways were entering what was then the western edge of the metropolitan area.

(Upon its opening, US 11 was rerouted to follow the Expressway from the Hampden terminus to Camp Hill, and thence up 32nd St to Market St. where it rejoined its old path.

Not until 1995 did work begin on the 3-mile section of PA 581 between the Harrisburg Expressway terminus and I-81 in the Good Hope area of Hampden Township.