Vocational programs offered include Automotive Technology; Business, Marketing, and Finance; Construction and Carpentry; Engineering and Robotics; Health Science; Precision Machining; Teacher Academy; and Welding.

[5] Harrison Central High School's Band has earned Straight Superior Ratings for the past 35 years, along with many national and international achievements.

[6] As of 2014, the band is under the direction of Ken White, Wil Richmond, Kristina Havard, Jeremy Smith and Dwight Hollingsworth.

[citation needed] The band has multiple programs that include marching, concert, symphonic, winter guard and indoor percussion.

[7] The JROTC "Red Rebel" Battalion, as of the 2020–21 school year, has approximately 50 cadets who learn the value of citizenship, leadership, community service, and teamwork.

The student council's main duties are to plan and produce many school functions including the prom and homecoming dances.

The National Honor Society (NHS) is an organization that recognizes the achievement and intellect of juniors and seniors at Harrison Central High School who not only excel in their classes, but also demonstrate the characteristics of scholarship, character, leadership, and service.

Every year the NHS participates in many service projects such as the Mississippi Coastal Cleanup, Salvation Army Blood Drive, and an “Unsung Heroes” luncheon for the uncertified staff of HCHS.

DECA is open to all students (10th-12th grade) enrolled in the Marketing Management Technology course at the Harrison County Career and Tech Center located on the HCHS campus.

[13] Harrison Central is home to a wide variety of sports, including but not limited to: archery, baseball, basketball, bowling, cross country, football, golf, powerlifting, soccer, softball, tennis, track, and volleyball.