In addition to serving portions of Gulfport and Biloxi, the district also serves the city of D'Iberville, the communities of Lizana, Lyman, Pineville, Saucier and Woolmarket, as well as most of rural Harrison County.

The Harrison County School District was created in 1957 as a result of a statewide reorganization plan passed into law by Mississippi Legislature.

Beginning in July 2023, the district began requiring students to wear clothing that matches the gender norms of the genders that they are designated as in the school computer system.

The racial makeup of the district was 33.9% African American, 48.7% White, 7.1% Hispanic, 2.6% Asian, 0.41% Native American, 0.36% Native Hawaiian or Pacific Islander, and 6.9% Two or More Races.

[3] 71.4% of the district's students participate in the federal free and reduced price meal program.