[1][2][3][4][5][6] Harona Esseku was born on August 14, 1934, in Krobonshie, Senya Beraku, in the Central Region.
[7][8] In 1959, he entered the University of Ghana and read an undergraduate degree course in economics obtained in 1962 on Texaco scholarship.
[7] He worked in the marketing department as a sales promotion manager for the Brong Ahafo and the then Northern Region.
[8] He took several foreign trips on sponsored trainings and was the advertising manager of Pioneer Tobacco by 1967.
At thirty-five years, Harona Esseku became the youngest cabinet minister in the Busia government, with responsibility for the Ministry of Transport and Communications.
[15] Esseku was deputy chairman of the national campaign committee of the party for the 2000 general elections.
[20] Harona Esseku was a beneficiary of the member of the Order of the Star of Ghana award, conferred on him by the then president John Agyekum Kufuor in 2007.