Filmed in Los Angeles, California, the series depicted eleven cisgender men in competition for a $250,000 reward over who could pass themselves off as a more convincing woman.

He's a Lady additionally received fierce criticism from the American Family Association, a Christian fundamentalist organization, who urged the series' sponsors to pull their advertisements and financial support due to concerns of misandry.

[1] The contestants initially believed that they were competing in a fitness competition titled All American Man; upon arrival, they learned that they would be required to cross-dress in an effort to pass themselves off as women.

[5] A contestant was eliminated from the competition each week at the discretion of a celebrity panel, which included Morgan Fairchild, Debbie Matenopoulos, and John Salley.

[citation needed] According to TBS spokesperson Gina McKenzie, the series was intended to "break down barriers between men and women" and illustrate how gender roles function in society.

"[11] Following the recent controversies and cancellations of other LGBT-themed reality television programs, executive producers Campbell and Douglas Ross were "anxious" to not offend the LGBT community.

[10] Through their consultation with GLAAD, Campbell claimed that the organization helped the producers to "bec[o]me more aware of transgender issues and the double standards of beauty.

[1] He's a Lady drew sharp criticism from Christian fundamentalist organizations, including the American Family Association and the Traditional Values Coalition.

S. C. Johnson & Son, who served as the series' principal sponsor, pulled their advertising and financial support due to pressure from the organizations.