It broadcast to Berkshire, Oxfordshire, north Hampshire and parts of west Buckinghamshire from studios in Reading, southern England.

Global Radio acquired GCap Media in 2008 and rebranded most of the One Network stations to Heart, in phases by area, from January 2009.

[3] On 26 February 2019, Global announced Heart Thames Valley would be merged with three sister stations in Hampshire and Dorset, Kent and Sussex and Surrey.

[4] From 3 June 2019, local output will consist of a three-hour regional Drivetime show on weekdays, alongside localised news bulletins, traffic updates and advertising.

[5] Heart Thames Valley ceased local programming on 31 May 2019, although the station's Reading studios were retained as offices for newsgathering and sales.