Hedwig of Mecklenburg-Güstrow (Hedwig Eleonore; 12 January 1666 – 9 August 1735), was a German noblewoman member of the House of Mecklenburg and by marriage Duchess of Saxe-Merseburg-Zörbig.

Born in Güstrow, she was the eighth of eleven children born from the marriage of Gustav Adolph, Duke of Mecklenburg-Güstrow and Magdalene Sibylle of Holstein-Gottorp.

[1][2][better source needed] In Güstrow on 1 December 1686, Hedwig married Prince August of Saxe-Merseburg, second surviving son of Duke Christian I.

Five years later (1691), August received the town of Zörbig as his appanage, and took his residence there.

They had eight children, of whom only one survived to adulthood:[3] Hedwig died in Zörbig aged 69.