[5] Hempfield offers a number of Advanced Placement courses, including classes in Biology, Calculus, Chemistry, Physics, Computer Science, Economics, Environmental Science, English, French, German, Spanish Literature, Art, Music Theory, Physics, Statistics, US History, Human Geography and US Government and Politics.

Hempfield High School is renowned for its extensive theater program and its annual Dance Theatre production.

[7] Created by Pat Kautter (choreographed and directed by Cody Smith, until 2021, switching to Devon Groff), this is a completely original show which features over 100 students.

[8] Hempfield's spring musical productions, under the direction of Alejandro Ramos and Cody Smith, are also known for their excellence.

The 1,300-seat Performing Arts Center[9] was designed by The Ray Group Inc.,[10] a Lancaster-based architecture firm that specializes in schools and universities.

[11] The PAC opened in the fall of 1995 and was one of the most expensive high school stages in Pennsylvania at the time.

The Chamber Singers perform the national anthem at many of Hempfield's home basketball games.

Led by Head Coach George Eager, the Hempfield football program has dramatically increased in performance in recent years.

They recently have had two straight berths to the PIAA District 3 AAAA playoffs and advanced to the quarterfinals both times.