The film stars Thomas Middleditch as a henchman-in-training, James Marsden as his mentor, Rosario Dawson as a scientist, and Alfred Molina as the super villain.

[4] A fallen henchman named Hank leads a team of Lester and two others, called the "Union of Evil", who must prevent Baron Blackout from dominating the world.

The crew are assigned to the Vault of Villainy, where Lester accidentally steals the ultimate weapon.

[5] The project was first announced on August 13, 2014, when Adam Wood's short film Henchmen: Ill Suited was released, with Gary Sanchez Productions (owned by Adam McKay, Will Ferrell and Chris Henchy) attached to executive produce the film for Bron Studios.

[6] On May 29, 2015, the full voice cast was revealed, including James Marsden, Thomas Middleditch, Rosario Dawson, Alfred Molina, Nathan Fillion, Jane Krakowski, Rob Riggle, Craig Robinson and Will Sasso.