Download coordinates as: Henderson Creek is a 64.6-mile-long (104.0 km)[2] tributary of the Mississippi River, which it joins in Henderson County, Illinois, near the villages of Gladstone and Oquawka.

[3] Henderson Creek rises in Knox County northwest of Wataga and flows west.

South Henderson Creek joins the stream in eastern Warren County, and Middle Henderson Creek joins farther west in Warren County.

Approximately 3 miles (5 km) downstream, Henderson Creek breaks through the bluffs forming the edge of the Mississippi River valley and proceeds 10 miles (16 km) farther southwest, running parallel to the Mississippi and collecting several small streams running off the bluffs, including Fall Creek and Jinks Creek.

This article related to a river in Illinois is a stub.