After also winning three domestic doubles, he signed for Bundesliga club Borussia Dortmund for a club-record fee of €27.5 million,[4] making him the most expensive Armenian player of all time.

His father was a prominent striker for FC Ararat Yerevan during the 1980s, who died of a brain tumor at age 33 when Henrikh was seven years old.

He has said, "I believe he sees me and is proud of me..."[13][14] His mother is the head of the national teams department in the Armenian Football Federation and his elder sister, Monika, works at UEFA's headquarters.

Armenia national football team and Pyunik head coach Vardan Minasyan admitted that he would love to see his star player "playing in a stronger league."

[32] Before signing with Shakhtar, Mkhitaryan was in trial with Iran Pro League side Mes Kerman which he was rejected by head coach Samad Marfavi.

[38] He made an appearance in the 2–0 Ukrainian Cup Final victory against Dynamo Kyiv, coming on in the 81st minute in place of Jádson.

[44] On 6 May 2012, he played a part in Shakhtar's 2–1 extra time victory over his former team Metalurh Donetsk in the Ukrainian Cup Final, coming off after 62 minutes for Douglas Costa.

Mkhitaryan debuted for Dortmund following his return from a three weeks sustained injury in the second round of 2013–14 Bundesliga on 18 August 2013 in a home victory over Eintracht Braunschweig at Signal Iduna Park.

[80] On 6 August 2015, Dortmund played against Wolfsberger AC in the third qualifying round second leg of the Europa League, Thomas Tuchel's first home match as coach.

[84] In the second round of the domestic cup on 28 October 2015, Mkhitaryan scored the final goal of a 7–1 rout of SC Paderborn 07.

[90][91] On 2 July 2016, Dortmund chief executive Hans-Joachim Watzke said that the sale of Mkhitaryan to England's Manchester United would be inevitable as the player would leave for free had he stayed one more year.

[96] On 7 August 2016, he made his competitive debut as a stoppage-time substitute in a 2–1 victory against Leicester City in the 2016 FA Community Shield.

[100] On 8 December 2016, Mkhitaryan scored his first goal for the club, away against Zorya Luhansk, in Manchester United's last group match of the Europa League.

[106] He scored in the 2017 Europa League final to help Manchester United beat Ajax 2–0,[107] and became the first Armenian to win a major European trophy.

On 22 January 2018, Arsenal announced the signing of Mkhitaryan from Manchester United, as part of a swap deal with Alexis Sánchez moving in the other direction.

[113] Mkhitaryan scored a goal and an assist in Arsenal's second games of the 2018–19 season against London rivals Chelsea, losing the match 3–2.

[123] Mkhitaryan played three games for Arsenal before, on 2 September 2019, he joined Italian club A.S. Roma on a season-long loan deal for €3 million, plus an additional €100,000 in variables.

[134] On 5 November 2020, Mkhitaryan scored the club's fastest-ever goal in the UEFA Europa League, after just 57 seconds, in a 5–0 defeat of Romanian outfit CFR Cluj.

[136] On 25 May 2022, Mkhitaryan was part of the starting eleven in the final of the UEFA Conference League against Feyenoord, which Roma won 1-0 with a goal from Nicolò Zaniolo.

[138] On 26 October, he scored his first Champions League goal with Inter in a 4–0 win over Viktoria Plzeň, which secured his club's qualification to the knockout phase.

[140] On 10 June 2023, he became the first Armenian to participate in the UEFA Champions League final, by making a substitute appearance against Manchester City.

On 10 September 2013, in the absence of regular skipper goalkeeper Roman Berezovsky, Mkhitaryan captained his country for the first time, as they lost 0–1 at home to Denmark in World Cup qualification.

[149] On 27 May 2014, he scored twice in a 4–3 friendly win against the United Arab Emirates at the Stade de la Fontenette in Carouge, Switzerland.

He is known for his ability to draw away opposing defenders and, in turn, create space for his teammates to exploit, leading to goal scoring opportunities, courtesy of his offensive movement, technique, and vision.

"[155] During the 2012–13 season, former Scottish footballer Pat Nevin said of Mkhitaryan, "Eleven goals in eight league matches already is fantastic, but when you add that he is a midfielder, it is phenomenal.

"[156] Mkhitaryan is a polyglot,[157] who speaks eight languages: Armenian, French, Portuguese, Russian, Ukrainian, English, Italian[158] and German.

[108] Shakhtar's Donbass Arena has a tradition of playing music each time home players score goals, with a track corresponding to the nationality of a scorer.

[15][160] In June 2019, Mkhitaryan married Betty Vardanyan at the monastery of San Lazzaro degli Armeni, near Venice, Italy.

In December 2011, Mkhitaryan visited Stepanakert, capital of the disputed territory, and donated gifts to the families of fallen soldiers.

[173] Pyunik[176] Shakhtar Donetsk[176] Borussia Dortmund[176] Manchester United[177] Roma Inter Milan Individual Orders