Konoplyanka began his professional career at Dnipro Dnipropetrovsk, where he made his debut in 2007 and featured in 211 matches across all competitions, scoring 45 goals and helping them to the 2015 UEFA Europa League Final.

[3] Konoplaynka's senior team debut came in a Ukrainian Premier League match on 26 August 2007 in a home game against Zakarpattia Uzhhorod which ended 0–0.

"[7] In January 2014, Konoplyanka nearly moved to English team Liverpool for £16 million, his buyout clause, but Dnipro president Ihor Kolomoyskyi refused to sanction the transfer.

[10] A week later, the Spanish club confirmed that he had joined on a free transfer, and signed a four-year deal, with a reported release clause of €40 million.

[11][12] On 11 August, he made his competitive debut for Sevilla in the 2015 UEFA Super Cup against Barcelona, as a 68th-minute substitute for captain José Antonio Reyes.

[14] Ten days later, after coming off the bench against Rayo Vallecano, he attained his first league goal for the Andalusians, winning the match 3–2 with a late free kick for a first victory of the season.

He played seven matches in their Copa del Rey campaign, scoring a late equaliser as a substitute in a 2–2 draw at Celta Vigo in the semi-finals (6–2 aggregate),[17] and also came off the bench in the final where they lost 2–0 to Barcelona after extra time.

On 9 August, he scored a penalty in the 2016 UEFA Super Cup against Real Madrid, an eventual 3–2 loss following extra time in Trondheim.

[27] He made his debut for the club on 3 August, in a 1–2 away loss to Adana Demirspor in the second qualifying round of the UEFA Europa Conference League.

In their opening game at the Olympic Stadium in Kyiv, he assisted Andriy Shevchenko's winning goal with a corner for a 2–1 victory against Sweden.

[33] He scored two more goals in Ukraine's qualifying campaign, in victories over San Marino and Montenegro, but the team lost to France in a play-off for the tournament.