Hermosa Creek is a tributary of the Animas River in San Juan and La Plata counties in Colorado.

The creek rises near Hermosa Peak in San Juan County, Colorado and then flows generally south to La Plata County and to its confluence with the Animas River in Hermosa.

In 2014, Congress passed and the president signed the Hermosa Creek Watershed Protection Act.

In 2018, the 416 Fire burned thousands of acres of the Hermosa Creek watershed.

Long known for its pristine and clear waters, the creek has been severely affected by the erosion occurring as a result of the fire.