[6] Prior to the official launch of his drink, Bagley held an extensive publicity campaign using posters spread throughout Buenos Aires.

[7] The poster campaign lasted three months until Hesperidina was finally launched on December 24, 1864, with an advertisement published in La Tribuna newspaper.

Alarmed by this development, Bagley convinced the president of Argentina, Nicolás Avellaneda, to create a patent and trademark office in 1876 in order to protect his product.

During the Triple Alliance War (1864–1870) Hesperidina was distributed among Argentine soldiers "to revitalize the wounded" because of its therapeutic effects on stomach problems associated with drinking non-potable water.

[1] The Hesperidina is mentioned in three short stories by Julio Cortázar: Casa Tomada, Tía en Apuros and Circe.

[10] Tango singer Roberto Goyeneche described Hesperidina as one of his favorite beverages,[11] which he used to drink at "La Sirena", a bar located on Balbín and Núñez streets in Saavedra, Buenos Aires.