Pro-hevein (Alternative name: Major hevein, gene name: HEV1) is a wound-induced[1] and a lectin-like protein from Hevea brasiliensis (rubber tree) where it is involved in the coagulation of latex.

[3] Hevein is the main IgE-binding epitope of the major latex allergen prohevein[4] as are hevein-like protein domains in fruit class I chitinases.

[5] Therefore it is a possible cause for allergen cross-reactivity between latex and banana or other fruits like chestnuts or avocadoes.

[6] Hevein-like genes can be found in many plants including Arabidopsis thaliana.

They correspond to the full Pro-Havein protein, the matur Hevein (N-terminal), and the C-terminal Barwin domain respectively.