Hexamethyldisiloxane

Hexamethyldisiloxane can be produced by the addition of trimethylsilyl chloride to purified water: It also results from the hydrolysis of silyl ethers and other silyl-protected functional groups.

[4] It reacts with rhenium(VII) oxide to give a siloxide:[5] HMDSO is used as an internal standard for calibrating chemical shift in1H NMR spectroscopy.

It is used in liquid bandages (spray-on plasters) such as cavilon spray, to protect damaged skin from irritation from other bodily fluids.

HMDSO is being studied for making low-k dielectric materials for the semiconductor industries by plasma-enhanced chemical vapour deposition (PECVD).

Following direct injection into tissues it has been used to generate maps of tumour and muscle oxygenation dynamics with respect to hyperoxic gas breathing challenge.

Stereo structural formula of hexamethyldisiloxane
Ball-and-stick model of the hexamethyldisiloxane molecule
NFPA 704 four-colored diamond Health 1: Exposure would cause irritation but only minor residual injury. E.g. turpentine Flammability 4: Will rapidly or completely vaporize at normal atmospheric pressure and temperature, or is readily dispersed in air and will burn readily. Flash point below 23 °C (73 °F). E.g. propane Instability 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g. liquid nitrogen Special hazards (white): no code