The series stars fictionalized and animated versions of the Japanese pop rock group Puffy AmiYumi.

Merchandise based on the series has also been produced, such as video games, home media releases, toys, and clothing.

They travel around the world on their customized tour bus along with their well-intentioned yet greedy manager Kaz Harada (voiced by Keone Young).

From rocking out at a concert to hanging out in their hometown of Tokyo, the duo take the world by storm with their musical talent, trend-setting style, and humor, dishing out lessons in J-pop justice and establishing the international language of "cool" along the way.

It also seems capable of running on autopilot, as Kaz, Ami, and Yumi are sometimes sitting in the rear cabin of the bus while traveling.

During the first season, the show included live-action clips of the real Ami and Yumi making childish commentary (in English and non-subtitled Japanese) at the beginning and end of each episode.

[2] However, it also has a cult following of teen and adult fans of the real-life Ami Onuki and Yumi Yoshimura who make up the Japanese pop duo Puffy AmiYumi.

Register, who was a fan of the band, wished to spread its fame to other parts of the world and thus created the series.

Sam Register originally pitched the idea of Puffy AmiYumi having their own television series on Cartoon Network, and afterwards, Renegade Animation developed a test short on April 22, 2003,[citation needed] in hopes of making the channel greenlight the show's production.

Renegade Animation originally, at first, created other Cartoon Network pilots before Hi Hi Puffy AmiYumi; two of which feature Captain Sturdy; one in 2001, entitled "Back in Action", and the other in 2003, entitled "The Originals", but they were ultimately rejected, and Renegade Animation then started working on Hi Hi Puffy AmiYumi starting with its pilot on April 22, 2003.

Finally, it was shown in non-full version as a preview on Cartoon Network DVDs and VHS tapes.

[7] The entire pilot was found by series' director, Darrell Van Citters, and was uploaded to Vimeo on April 5, 2018.

[11] On October 2, 2006, the show's crew announced on their blog that Cartoon Network had cancelled Hi Hi Puffy AmiYumi after three seasons and 39 episodes due to management shakeup, leading Sam Register to leave the channel, until Register officially became the president of Cartoon Network Studios on August 28, 2020.

[17] The Los Angeles Times wrote that the show is "modern, in its retro, Asian-tinged way -- in other words, right in line with the Cartoon Network aesthetic -- but nothing new", and called it "bright and loud and sensational".

The show charted double-digit increases with Girls 6–11 in ratings and delivery for Cartoon Network's Fridays programming block.