It lies upon what was the A10, however the A10 Wadesmill by-pass has now been built around High Cross and neighbouring villages.

Sections of the A10 that used to run through High Cross and the neighbouring settlements such as Wadesmill were once part of the Roman road, Ermine Street.

It is 4.6 km (2.9 miles) north of the town of Ware and 7 km (4 miles) north east of the county town of Hertford.

[1] Some nearby settlements include the villages of Thundridge and Wadesmill to the south, the hamlets of Colliers End to the north, Dane End to the west and Barwick to the east.

High Cross contains Puller Memorial Primary school, St John the Evangelist Church, and formerly the White Horse Pub which closed down in 2017.