In September 2008, High Point athletics director Craig Keilitz announced the formation of a women's lacrosse team.

Boswell was a 2005 graduate of Pfeiffer, where she was a two-time IWLCA All-American and was the Carolinas-Virginia Athletics Conference player of the year in 2004.

In June 2009, Boswell became head coach at High Point,[3] and after a year and a half of recruiting, the Panthers' first Division I season was in spring 2011.

In 2013 the Big South Conference began sponsoring women's lacrosse and was also granted an automatic berth to the NCAA tournament.

While they lost all four, the stiff competition prepared them well for the Big South, where they swept the rest of the teams en route to another NCAA tournament appearance, an 18-4 loss to Notre Dame.

[9] 2017 saw the Panthers get off to a rough start, falling to eventual NCAA Tournament teams North Carolina, Elon, and James Madison.

[11] The program garnered its first NCAA tournament win (and the first in High Point Panthers history) by defeating Towson, 21-15.

[13] In 2018, led by Tewaaraton Award Watch List nominee Erica Perrotta, and freshman Abby Hormes, who scored 59 goals, the Panthers returned to the NCAA tournament.

After two early losses to eventual top-3 seeds UNC and James Madison, the Panthers rattled off sixteen straight wins, including triumphs over at the time #21 Notre Dame and #19 Duke.

The season took a big turn after toppling #14 Johns Hopkins 13-10, which is the highest ranked win against a top 25 team in program history.

[18] The team partners with the Friends of Jaclyn Foundation, which is "an organization created to encourage NCAA athletic programs to sponsor pediatric brain tumor patients".