Hisai Domain (久居藩, Hisai-han) was a feudal domain under the Tokugawa shogunate of Edo period Japan, located in Ise Province in former Hisai town (now part of the modern-day city of Tsu, Mie Prefecture).
On them other hand, the parent house suffered frequently from lack of a direct heir, and many of the daimyō of Tsu Domain assumed that post after gaining experience in administering Hisai.
However due to the reforms initiated by the 12th daimyō of Tsu, Tōdō Takasato, the finances of the domain were restored.
After his death, problems arose again, until the time of the 15th daimyō Tōdō Takayori in the Bakumatsu period, with the development of new rice lands and flood control works on the Kumozu River.
Following the establishment of the Meiji government and the 1871 abolition of the han system, the territory of Hisai Domain became part of Mie prefecture in 1876.