Following the 1600 Battle of Sekigahara, Tokugawa Ieyasu reinstated Tomita Nobukane as daimyō of Tsu Domain, with an increase in kokudaka to 70,000 koku.

Although a tozama daimyō, Tōdō Takatora received special treatment from Tokugawa Ieyasu from an early stage, and had been entrusted with the construction of Edo Castle.

However, on the retirement of Tōdō Takatsugu in 1669, 50,000 koku of his holdings were split off to allow his second son to establish a cadet branch of the clan at Hisai Domain.

[1] The situation deteriorated again under the 11th daimyō, Tōdō Takayuki, and natural disasters such as bad harvests and earthquakes occurred one after another, driving the domain deeply into debt.

With the start of the Boshin War, he proclaimed the domain's neutrality, stating that he refused to participate in what he viewed as a private feud between Satsuma and Aizu.

However, after the Battle of Toba-Fushimi, he was visited by a messenger from Emperor Meiji, and his local commanders decided to assist the Satchō Alliance by attacking the retreating shogunate forces.