Financial problems during the winter, however, prevented the team from preparing or testing the chassis, as Campos was unable to pay Dallara, or engine suppliers Cosworth.

He noted the precise aerodynamic sculpting around the sidepods and engine air intake, the "V" profile of the nose derived from the previous year's Red Bull RB5 chassis, and the triple-plane front wing.

[9] Geoff Willis, who was later recruited as the team's technical consultant, said that he was "disappointed at the level of engineering in the car" and that he did not think that it "reflects current F1 practise by quite some margin", even allowing for the disrupted construction process.

[1] In 2020, Karun Chandhok – who took part in 10 Grands Prix for Hispania – claimed that the battle between Campos and Dallara over the chassis payment led to the team's launch car being raced all season without any upgrades.

[18] During Saturday's sole practice session, Senna completed 11 more laps, and trimmed his time to within ten seconds of the pace, but Chandhok was further delayed by a hydraulic problem.

In the race both cars ran efficiently and achieved the F110's first double-finish, with Chandhok and Senna finishing in 15th and 16th positions respectively, ahead of the two delayed Lotus drivers.

[25] At the Chinese Grand Prix, Chandhok received a five-place grid penalty as the team broke the Fédération Internationale de l'Automobile (FIA) seal on his car's gearbox without a representative of the governing body being present; he was then further penalised for his mechanics changing a hydraulic pump assembly with parts of a different specification to the originals, and was made to start from the pit lane.

[28] The team's test driver, Christian Klien, drove the F110 for the first time in free practice for the Spanish Grand Prix, replacing Chandhok for the first session.

[32] In the race, both cars ran ahead of Jarno Trulli's delayed Lotus in the closing stages, but Senna retired with a hydraulic failure on lap 58, whilst Trulli's attempt to pass Chandhok eight laps from the finish resulted in the two cars colliding and retiring from the race, although Chandhok was classified in 14th position.

[35] Senna outqualified Di Grassi whilst Chandhok qualified last, but both cars retired with mechanical problems in the race.

[36][37] At the Canadian Grand Prix, Chandhok missed the third free practice session and did not set a representative time in qualifying due to hydraulic and sensor problems, but Senna outqualified Di Grassi to take 22nd place on the grid.

Senna, who qualified ahead, was then elevated to 22nd position when Kamui Kobayashi (Sauber) was given a penalty for failing to stop at the pit-lane weighbridge when requested.

In the race, however, Senna retired early after suffering a suspension failure which caused him to spin, whilst Yamamoto finished, albeit a place lower than he had started.

The drivers qualified slowest, with Senna again ahead, and were then elevated a position each when Glock received a grid penalty for an unscheduled gearbox change.

[55] In his first competitive outing since the 2006 Brazilian Grand Prix, Klien outqualified Senna by more than a second; both Hispania cars lined up ahead of Felipe Massa's Ferrari on the grid, as he had failed to set a time during the session.

[56] Yamamoto returned to the driving seat for his home race in Japan; he qualified a tenth of a second behind Senna on the back row of the grid.

In the race, Senna made a pit stop on the first lap, along with several other drivers, in response to a safety-car period caused by two first-lap accidents.

[57][58] Yamamoto outqualified Senna for the first time at the inaugural Korean Grand Prix, taking 23rd place on the grid, only a tenth of a second behind Di Grassi.

[62][64] Hispania used the F110 in pre-season testing for the 2011 season, and continued to do so until the new car, designed by Willis and featuring a Williams hydraulic system, was completed.