The station is located in the network of the Verkehrsverbund Rhein-Neckar (Rhine-Neckar transport association, VRN) and belongs to fare zone 100.

It became a junction station on 29 October 1870, with the opening of the Alsenz Valley Railway (Alsenztalbahn) to Winnweiler; half a year later this line was extended to Bad Münster.

[5] The zero point for the line-kilometre calculation is between Bexbach and Neunkirchen on the former Bavarian–Prussian national border on what is now part of the Homburg–Neunkirchen railway, although different chainages are now used on that line.

[8] The then mayor Wilhelm Ritter convinced the Palatine Ludwig Railway Company (Pfalzische Ludwigsbahn-Gesellschaft) of its merits, so that finally a station was developed on the western outskirts.

[9] A connecting curve to Hochspeyer was built to the south of Fischbach to allow through train to run to Kaiserslautern.

The newly created junction station was called Neuhochspeyer or Neu-Hochspeyer (both meaning "new Hochspeyer") by the railway company at different times.

[14] As the Mannheim–Saarbrücken railway has always been of great importance for long-distance traffic, it was gradually electrified, starting in 1960.

The Homburg–Kaiserslautern section followed on 18 May 1961 and, on 12 March 1964, the entire length of the route, including Hochspeyer station, was electrically operated.

The electrification of the remaining section had been delayed mainly because of the numerous tunnels between Kaiserslautern and Neustadt, which had to be enlarged.

In the course of the gradual dissolution of the railway division of Mainz from 1 August 1971, its counterpart in Saarbrücken took responsibility for the station.

The two locomotives of both trains were demolished and an affected UIC-X wagon was for some time abandoned on a siding in Hochspeyer.

[18] Since 1996 the station has been in the area covered by the Verkehrsverbundes Rhein-Neckar (Rhine-Neckar transport association, VRN).

[31] In 1871, the journey time from Hochspeyer station to Kaiserslautern lasted between 17 and 19 minutes for passenger trains and to Neustadt it took at least three-quarters of an hour.

[33] The trains of the Alsenz Valley Railway ran in the summer of 1914 on the Bad Münster–Neustadt route, reversing in Hochspeyer.

[36] The station is served by S-Bahn services on line S1 (Homburg–Osterburken) and S2 (Kaiserslautern–Mosbach), both running hourly, which results in a half-cycle between Kaiserslautern and Mosbach.

Since 2005, services have run on Sundays and public holidays from May to October from Hochspeyer via the Zeller Valley Railway to Worms.

In 1871, normal freight trains on the Ludwigs Railway stopped between three and five minutes at the station.

In addition, there was a so-called "supplemental freight train" that stopped at only the stations of Enkenbach, Winnweiler, Rockenhausen, Alsenz and Ebernburg between Kaiserslautern and Münster.

At the beginning of the twentieth century, freight trains running on the Ludwigshafen–Kaiserslautern, Kaiserslautern–Bingerbrück and Marnheim–Neustadt–Kaiserslautern routes stopped at the station.

In addition, the station is the starting point of Tour 4 of the Palatine Forest Mountain Bike Park (Mountainbikepark Pfälzerwald).