Hoffer Creek is a tributary of the Susquehanna River in Snyder County, Pennsylvania, in the United States.

At least part of the creek is designated as an impaired waterbody due to sedimentation/siltation from grazing-related agriculture.

The creek is in the ridge and valley physiographic province, and the geology consists mostly of intermedded sedimentary rock and sandstone.

It flows east-southeast for a few tenths of a mile, passing through another pond and receiving an unnamed tributary from the left.

[1] Hoffer Creek joins the Susquehanna River 107.34 miles (172.75 km) upstream of its mouth.

[3] The average annual rate of rainfall in the watershed of Hoffer Creek over a 19-year period was approximately 39.3 inches (100 cm).

The average annual rate of runoff in the watershed during a 19-year period was approximately 2.9 inches (7.4 cm).

[3] The level of slope in the watershed of Hoffer Creek, combined with the lack of conservation farming practices in the upper reaches of the watershed, causes fast-moving silty runoff to form during precipitation events, degrading the creek and all its tributaries.

[5] The Pennsylvania Department of Transportation was once issued an Encroachment permit to build and maintain an articulated grout mattress in Hoffer Creek, under a bridge carrying State Route 2002.

[6] In June 2012, the Pennsylvania Department of Environmental Protection invited comments on its proposed total maximum daily load for Hoffer Creek.

Additionally, livestock have access to the creek and conservation farming practices are not done in the watershed.