Holliday Creek is a stream in Wayne County in the U.S. state of Missouri.
The stream headwaters arise north of Missouri Route E west of the community of Burbank at 37°09′28″N 90°23′33″W / 37.15778°N 90.39250°W / 37.15778; -90.39250.
The stream flows southwest passing southeast of Greenville and enters the waters of Lake Wappapello.
The confluence with the St. Francis prior to the lake formation was just southeast of the US Route 67 bridge at 37°05′42″N 90°26′56″W / 37.09500°N 90.44889°W / 37.09500; -90.44889.
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