Holmes County Central High School is a senior high school in unincorporated Holmes County, Mississippi, United States, about 0.25 miles (0.40 km) south of Lexington.

[8] Stanford University Graduate School of Education Center to Support Excellence in Teaching (CSET) stated that "Despite concerns by some in the community, the merging of the high schools has been a success.

"[7] In March 2018 the newly elected Holmes County school board voted to move high school students in Durant High School to Holmes County Central High, an action opposed by area residents.

As of 2017[update] it is considering acquiring a former factory, which would only need $20 million to be renovated into a high school.

[8] In 2015 about 66% of incoming 9th graders had reading scores below their intended grade levels.