A hologenome is the whole set of genomes of a holobiont, an organism together with all co-habitating microbes, other life forms, and viruses.
[12] Ubiquity testing also revealed many different bacterial and algal symbionts that are not associated with a single species of coral,[13] suggesting that hologenomics just identifies and validates mechanistic interactions between pathogens, microbes, and their hosts.
[14] It's hypothesized the continued incidence non-infectious diseases is a result of modernization reducing the diversity of symbiotic microbes.
Disease biomarkers can be found by investigating lifestyle, genomic differences, and mRNA/protein/metabolite profiles of the patient and their microbiota.
[24] Understanding microorganism recognition of foreign pathogenic invasion and how host immunity favors the most ideal symbiont may aid in discovering novel therapeutic treatments to combat evolving diseases.