Hologenomics

A hologenome is the whole set of genomes of a holobiont, an organism together with all co-habitating microbes, other life forms, and viruses.

[12] Ubiquity testing also revealed many different bacterial and algal symbionts that are not associated with a single species of coral,[13] suggesting that hologenomics just identifies and validates mechanistic interactions between pathogens, microbes, and their hosts.

[14] It's hypothesized the continued incidence non-infectious diseases is a result of modernization reducing the diversity of symbiotic microbes.

Disease biomarkers can be found by investigating lifestyle, genomic differences, and mRNA/protein/metabolite profiles of the patient and their microbiota.

[24] Understanding microorganism recognition of foreign pathogenic invasion and how host immunity favors the most ideal symbiont may aid in discovering novel therapeutic treatments to combat evolving diseases.

Distinct microbial communities in sponges converge to have common functionality despite retaining phylogenetic differences. [ 10 ]