[1] It is named after the Holy Family of Jesus and is a part of the San Pedro Pastoral Region in the Archdiocese of Los Angeles.

Manuel Vicente arrived in Artesia in 1929 and organized church supporters, holding masses in the Scott and Frampton Building until it was completed.

Vicente also trained altar servers, had youth classes, created a choir, and formed the first Society of the Holy Name division in the Western Coast of the U.S.[4] Groundbreaking on the church site took place on the same day it was founded, December 25, 1930.

Some of the debt from building the church was paid for by Vicente's minor role as a priest in the major motion picture Tiger Shark in 1932.

Patrick O'Connor, one of Vicente's successors starting in 1943, envisioned the growth of the church to include ministries and religious education.

[4] John Twomey, the pastor during the 1980s, created a committee that remodeled the rectory, and added a meeting hall, kindergarten, and computer lab.

Roger Mahony assigned the parish to the Marian Missionaries of the Holy Cross in 2010, a Philippine-based congregation, and the two most recent pastors, Raymond Decipeda and John Cordero, are a part of the organization.

In addition to this, it also held live conversations from a building adjacent to the church property, 18616 Seine Ave, called the Blessed Carlo Acutis Broadcast Center.

[1] A $60,000 statue of Jesus, Mary, and Joseph, the Holy Family, was made by Rhode Island–based Artisan Granite and placed in the front of the church, being blessed on September 8, 2013.

[6] On December 12, 2018, the same day as the feast of Our Lady of Guadalupe, a stain appeared on a church-owned sidewalk that had a resemblance to the Virgin Mary.