Holy Trinity Ukrainian Orthodox Cathedral is a Ukrainian Orthodox Cathedral in Vancouver, British Columbia, Canada, on East 10th Avenue just west of Main Street.

The Holy Trinity Ukrainian Orthodox Parish was established in Vancouver on May 9, 1937.

The first Holy Liturgy was held on July 18, 1937, at the Ukrainian National Home.

In 1970 the parish commenced planning and fundraising for the building of a two-level Ukrainian Orthodox Centre attached to the church and officially opened on June 17, 1973.

In December 1977, Vancouver City Council designated the church an architectural heritage building, and an engraved plaque was placed on its exterior.