As Commissioner-General of the Adelsverein, he founded the city of Fredericksburg, and opened up the Fisher–Miller Land Grant territory to settlement when he brokered the Meusebach–Comanche Treaty.

His Loyal Valley homesite was designated a Recorded Texas Historic Landmark in 1969, Marker number 11288.

Nimitz later gave an interview about the visit to the Fredericksburg newspaper Das Wochenblatt, detailing the orchards and gardens Meusebach had cultivated.

On his acreage he indulged in his love of horticulture by maintaining an orchard, ornamental shrubs and a personal rose garden.

Meusebach opened a mercantile establishment that evolved into a stage stop and the area's community gathering place, where he survived a gunshot wound to the leg, inflicted by trouble makers during the Mason County Hoo Doo War.