Honey Brook is a borough in Chester County, Pennsylvania, United States.

The owner of the surrounding property, Andrew Boyer, established a town plan for the village of Waynesburg (named in honor of Revolutionary War general Mad Anthony Wayne) and began selling lots in June 1813.

Honey Brook is an incorrect English translation of Nantmel, a village in Radnorshire, now part of Powys.

The Welsh name Nantmel actually means 'Maël's valley', Maël being a tenth-century prince.

In 1884 the railroad from Philadelphia-Downingtown-Lancaster was completed and ran along the south side of Horseshoe Pike.

The freight was being routed to the wrong stations, so the name was changed from Waynesburg to Honey Brook.

With the incorporation as a borough, the main problems to overcome were: street lighting, sidewalks, and, several years later, water.

[4] According to the United States Census Bureau, the borough has a total area of 0.5 square miles (1.3 km2), all land.

The borough lies on a ridge between the headwaters of the east and west branches of the Brandywine Creek.

At the 2010 census, the borough was 93.1% non-Hispanic White, 1.1% Black or African American, 0.2% Asian, 0.1% Native Hawaiian or other Pacific Islander, and 3.2% were two or more races.

U.S. Route 322 crosses the central part of the borough on a northwest-to-southeast alignment via Horseshoe Pike.