Hoogezand-Sappemeer (Dutch pronunciation: [ɦoːɣəˌzɑnt sɑpəˈmeːr] ⓘ) is a former municipality in the Northeastern Netherlands.

It was formed in 1949 by the merger of the former municipalities of Hoogezand (well-known for its ship building industry) and Sappemeer.

On 1 January 2018, Hoogezand-Sappemeer merged with Slochteren and Menterwolde, forming the new municipality Midden-Groningen.

There is also a railway line providing service to Groningen and Nieuweschans/Leer(Germany).

Trains serve four stations in the municipality, Kropswolde, Martenshoek, Hoogezand-Sappemeer, and Sappemeer Oost.