Recent commercial additions include a bakery/sandwich shop, a French restaurant, a coffee roastery, an art gallery and bistro, and a barbecue joint with a live music venue.

Wood Mowing & Reaping Company was the largest farm machinery manufacturer in the world, taking up 85 acres (340,000 m2) on the west bank of the river.

The only buildings still in use today are outside of the main complex, the Interface Solutions Plant (formerly the Wood-Flong Paper Mill), which was Walter A Wood's steel foundry.

Hoosick Falls once had factories that made paper, small numbers of appliances, glass, and some nominal soda and beer bottling plants.

Grandma Moses, the American folk artists who rose to fame after her work was discovered in Thorpe's Pharmacy in downtown Hoosick Falls by a passing New York City art dealer, was born close by and is buried in the Maple Grove Cemetery.

Jose De Creeft, the Spanish-born artist and sculptor best known for his sculpture of Alice in Wonderland in New York's Central Park kept a home in the village and is buried there.

Yucel Erdogan, the NYC artist and photographer, operates the 3rd Eye Gallery in a renovated department store in the downtown commercial district.

The downtown hosts two significant murals, one by local artist Roger Weeden, that depicts the Grandma Moses painting, "Wagon Repair Shop".

Concern developed locally in 2014, and in December 2015, the Village advised residents to use bottled water provided for free by Saint-Gobain, the current owner of the plastics facilities.

[9] The contamination of Hoosick Falls’ water was originally discovered by resident Michael Hickey following the death of his father from an aggressive kidney cancer, which was diagnosed after his retirement from the Saint-Gobain Performance Plastics plant.

Hickey noted the elevated rate of cancer diagnoses and deaths in their village, and began looking into the effects of the chemicals used in local manufacturing plants.

[11] PFOA, which belongs to a group of chemicals called per- and polyfluoroalkyl substances (PFAS) used to make household and commercial products, has been shown to cause reproductive, developmental, liver, kidney, and immunological effects in laboratory animals.

[12] Much of the focus of investigation and litigation has been on the Saint-Gobain Performance Plastics facility, which is located next to the village water treatment plant and began manufacturing with PFOA in 1999.

[12] Hickey tested water samples from his kitchen sink and businesses in the village, and discovered a PFOA level of 540 parts per trillion, exceeding the existing EPA guideline at the time of 400 ppt by 35%.

[12] In December 2015, the Village advised residents to use bottled water provided for free by Saint-Gobain, the current owner of the plastics facilities and the party responsible for the pollution mitigation.

[12] The New York State Department of Environmental Conservation (NYSDEC) is leading the investigation and cleanup of the McCaffrey Street site, with support from the EPA.

In June 2016 Saint-Gobain Performance Plastics and Honeywell International were deemed “potentially responsible parties” for the contamination, and entered into a consent order with the NYSDEC.

[11][10] Throughout the court proceedings attorneys for Saint-Gobain and Honeywell moved for the case to be dismissed, claiming that “mere accumulation of elevated levels of PFOA in the blood did not constitute physical injury”[17] and that “in the absence of physical damage, 532 Madison, 96 N.Y.2d 280, 727 9 N.Y.S.2d 49, precludes recovery in tort for harm that is exclusively economic, and that because ‘groundwater is not private property,’ plaintiffs could not base property damage claims on ‘alleged injury to groundwater’.

Public transportation to and from the village is provided between Albany and Bennington, Vermont by Yankee Trails World Travel's weekday-running Albany-Bennington Shuttle bus.