The initial promoters of HOMS were: Dr. Rafael Sánchez Español, a very well recognized medical doctor in Santiago; Dr. José Hazim Frappier, former Senator of San Pedro de Macorís who is currently Chancellor of Universidad Central del Este in San Pedro de Macorís, Dominican Republic;[2] Sonia Dillon, Ph.D, a graduate from University of Pittsburgh, Eduardo Estrella,[3] Civil Engineer who created the hospital's Structural design and Ernesto Moquete, Electric Engineer who created the electrical wiring and panels for the hospital.

The construction of HOMS was paralyzed for three years due to the country suffering economic difficulties during the PRD government headed by Hipólito Mejía.

These entrepreneurs are: Félix García, Manuel Estrella, Fernando Capellán, Carlos Sully Fondeur, Angel Rosario Viñas, and José Clase, among others.

Individually, they are owners of Dominican newspapers, TV stations, Industrial Free Zones and several other businesses.

LECOM is the nation's largest medical school in the United States with more than 1400 students and has three campuses, two located in Pennsylvania and the other one in Bradenton, Florida.